Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections

@inproceedings{Manickam2018CytokineMediatedTI,
  title={Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections},
  author={Cordelia Manickam and Spandan V. Shah and Olivier Lucar and Daniel R Ram and R Keith Reeves},
  booktitle={Front. Immunol.},
  year={2018}
}
Viral infections trigger robust secretion of interferons and other antiviral cytokines by infected and bystander cells, which in turn can tune the immune response and may lead to viral clearance or immune suppression. However, aberrant or unrestricted cytokine responses can damage host tissues, leading to organ dysfunction, and even death. To understand the cytokine milieu and immune responses in infected host tissues, non-human primate (NHP) models have emerged as important tools. NHP have… CONTINUE READING
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