Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

  title={Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling},
  author={Mia C. {\AA}kerfeldt and Jennifer M Howes and Jeng Yie Chan and Veronica A. Stevens and Nacer Boubenna and Helen M McGuire and C Christopher King and Trevor J Biden and D. Ross Laybutt},
  pages={3034 - 3044}
OBJECTIVE Cytokines contribute to beta-cell destruction in type 1 diabetes. Endoplasmic reticulum (ER) stress-mediated apoptosis has been proposed as a mechanism for beta-cell death. We tested whether ER stress was necessary for cytokine-induced beta-cell death and also whether ER stress gene activation was present in beta-cells of the NOD mouse model of type 1 diabetes. RESEARCH DESIGN AND METHODS INS-1 beta-cells or rat islets were treated with the chemical chaperone phenyl butyric acid… CONTINUE READING
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