Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐10

@article{Poole1995CytokinemediatedIH,
  title={Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐10},
  author={Stephen Poole and Fernando de Q Cunha and Stephen M. Selkirk and Berenice B. Lorenzetti and Sérgio Henrique Ferreira},
  journal={British Journal of Pharmacology},
  year={1995},
  volume={115}
}
1 The effect of interleukin‐10 (IL‐10) upon the hyperalgesic activities in rats of bradykinin, tumor necrosis factor α (TNFα), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), prostaglandin E2 (PGE2) and carrageenin were investigated in a model of mechanical hyperalgesia. 2 Hyperalgesic responses to bradykinin (1 μg) were inhibited in a dose‐dependent manner by prior treatment with IL‐10 (1–100 ng). 3 Hyperalgesic responses to TNFα (2.5 pg), IL‐1β (0.5 pg) and IL‐6 (1.0 ng… 

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