Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program

@inproceedings{Park2016CytokineinducedMD,
  title={Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program},
  author={Hyun Jung Park and Juan Li and Rebecca Hannah and Simon C. Biddie and Ana I Leal‐Cervantes and Kristina Kirschner and David Flores Santa Cruz and Veronika Sexl and Berthold G{\"o}ttgens and Anthony R Green},
  booktitle={The EMBO journal},
  year={2016}
}
Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in which tyrosine-phosphorylated STATs (pSTATs) function as transcription factors. However, the mechanisms by which STAT activation modulates lineage-affiliated transcriptional programs are unclear. We demonstrate that in the absence of thrombopoietin (TPO), tyrosine… CONTINUE READING
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