Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

@article{Tam2012CytokeratinsME,
  title={Cytokeratins mediate epithelial innate defense through their antimicrobial properties.},
  author={Connie Tam and James J. Mun and David J. Evans and Suzanne M. J. Fleiszig},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 10},
  pages={
          3665-77
        }
}
Epithelial cells express antimicrobial proteins in response to invading pathogens, although little is known regarding epithelial defense mechanisms during healthy conditions. Here we report that epithelial cytokeratins have innate defense properties because they constitutively produce cytoprotective antimicrobial peptides. Glycine-rich C-terminal fragments derived from human cytokeratin 6A were identified in bactericidal lysate fractions of human corneal epithelial cells. Structural analysis… CONTINUE READING

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