Cytokeratin 8-MHC class I interactions: a potential novel immune escape phenotype by a lymph node metastatic carcinoma cell line.

@article{Wu2013Cytokeratin8C,
  title={Cytokeratin 8-MHC class I interactions: a potential novel immune escape phenotype by a lymph node metastatic carcinoma cell line.},
  author={Ming-Syue Wu and Chia-hsuan Li and Jan Gustav Ruppert and Chien-Chung Chang},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={441 3},
  pages={618-23}
}
Defective human leukocyte antigen (HLA) class I expression in malignant cells facilitates their escape from destruction by CD8(+) cytotoxic T lymphocytes. In this study, a post-translational mechanism of HLA class I abnormality that does not involve defects in the HLA subunits and antigen processing machinery components was identified and characterized. The marked HLA class I downregulation phenotype of a metastatic carcinoma cell line can be readily reversed by trypsin, suggesting a masking… CONTINUE READING

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