Cytokeratin 5-Positive Cells Represent a Therapy Resistant subpopulation in Epithelial Ovarian Cancer.

@article{Corr2015Cytokeratin5C,
  title={Cytokeratin 5-Positive Cells Represent a Therapy Resistant subpopulation in Epithelial Ovarian Cancer.},
  author={Bradley R. Corr and Jessica Finlay-Schultz and Rachel B Rosen and Lubna Qamar and Miriam D. Post and Kian Behbakht and Monique A. Spillman and Carol A. Sartorius},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2015},
  volume={25 9},
  pages={
          1565-73
        }
}
OBJECTIVE Cytokeratin 5 (CK5) is an epithelial cell marker implicated in stem and progenitor cell activity in glandular reproductive tissues and endocrine and chemotherapy resistance in estrogen receptor (ER)(+) breast cancer. The goal of this study was to determine the prevalence of CK5 expression in ovarian cancer and the response of CK5(+) cell populations to cisplatin therapy. MATERIALS AND METHODS Cytokeratin 5 expression was evaluated in 2 ovarian tissue microarrays, representing 137… CONTINUE READING
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