Cytokeratin-20 reverse-transcriptase polymerase chain reaction as a new tool for the detection of circulating tumor cells in peripheral blood and bone marrow of bladder cancer patients.

@article{Retz2001Cytokeratin20RP,
  title={Cytokeratin-20 reverse-transcriptase polymerase chain reaction as a new tool for the detection of circulating tumor cells in peripheral blood and bone marrow of bladder cancer patients.},
  author={Margitta Retz and Joachim Lehmann and Christian R{\"o}der and K. Weichert-Jacobsen and Tillmann Loch and E Romahn and Christof L{\"u}hl and Holger Kalthoff and Michael St{\"o}ckle},
  journal={European urology},
  year={2001},
  volume={39 5},
  pages={507-15; discussion 516-7}
}
OBJECTIVES Systemic progression is the prevalent form of bladder tumor recurrence after radical cystectomy. The ability to detect circulating tumor cells in peripheral blood or bone marrow could be of prognostic value for the disease with the consequence of early adjuvant chemotherapy. We established a sensitive and specific method using a double cytokeratin-20 (CK-20) reverse-transcriptase polymerase chain reaction (RT-PCR) to detect circulating bladder cancer cells in venous blood and bone… CONTINUE READING