Cytokeratin 20-negative Merkel cell carcinoma is infrequently associated with the Merkel cell polyomavirus

@article{Miner2015Cytokeratin2M,
  title={Cytokeratin 20-negative Merkel cell carcinoma is infrequently associated with the Merkel cell polyomavirus},
  author={Andrew G Miner and Rajiv M Patel and Deborah A. Wilson and Gary W. Procop and Eugen C. Minca and Douglas Randall Fullen and Paul W Harms and Steven D Billings},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={498-504}
}
Merkel cell carcinoma is a rare, highly aggressive cutaneous neuroendocrine carcinoma most commonly seen in sun-damaged skin. Histologically, the tumor consists of primitive round cells with fine chromatin and numerous mitoses. Immunohistochemical stains demonstrate expression of neuroendocrine markers. In addition, cytokeratin 20 (CK20) is expressed in ∼95% of cases. In 2008, Merkel cell carcinoma was shown to be associated with a virus now known as Merkel cell polyomavirus in ∼80% of cases… CONTINUE READING
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