Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.

Abstract

Adhesion is a key component of hematopoietic stem cell regulation mediating homing and retention to the niche in the bone marrow. Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Knockdown of CYTH1… (More)
DOI: 10.1182/blood-2016-06-720649

Topics

5 Figures and Tables

Cite this paper

@article{Rak2017Cytohesin1R, title={Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.}, author={Justyna Rak and Katie Eloise Foster and Katarzyna Potrzebowska and Mehrnaz Safaee Talkhoncheh and Natsumi Miharada and Karolina Komorowska and Therese Torngren and Anders Kvist and {\AA}ke Borg and Lena Svensson and Dominique Bonnet and Jonas Larsson}, journal={Blood}, year={2017}, volume={129 8}, pages={950-958} }