Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.

@article{Mimura2010CytoglobinAN,
  title={Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.},
  author={Imari Mimura and Masaomi Nangaku and Hiroshi Nishi and Reiko Inagi and Tetsuhiro Tanaka and Toshiro Fujita},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 5},
  pages={
          F1120-33
        }
}
Cytoglobin (Cygb), a novel member of the globin superfamily, is expressed by fibroblasts in various organs. However, its function remains unknown. Because of its localization, we speculated that a biological role of Cygb may be related to fibrogenesis. To clarify the role of Cygb in kidney fibrosis, we employed the remnant kidney model in rats. Immunohistochemical analysis showed an increase in Cygb expression in parallel with disease progression. To investigate the functional consequence of… 
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Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.
Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice
TLDR
Cell-specific overexpression of Cygb attenuates HSC activation and protects mice against TAA-induced liver fibrosis presumably by maintaining HSC quiescence, and is a potential new target for antifibrotic approaches.
The anti-oxidative role of cytoglobin in podocytes: implications for a role in chronic kidney disease.
TLDR
A podocyte-related renal role of Cygb is demonstrated, abundant CYGB expression in human podocyte cell lines is confirmed, and for the first time an association between CYGB and chronic kidney disease is described.
Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family
TLDR
Recently, Cygb has been shown to inhibit cancer cell growth in vitro, thus confirming its suggested tumour suppressor role and potential clinical utility.
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
TLDR
The current perception of the distribution, regulation and function of Cygb with regard to liver diseases, with an emphasis on its role in tumorigenesis, is discussed.
Absence of cytoglobin promotes multiple organ abnormalities in aged mice
TLDR
The absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.
Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.
Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice
TLDR
Cygb deficiency in HSCs enhances hepatocyte damage and inflammation in early phase and fibrosis development in late phase in mice subjected to BDL, presumably via altered NO metabolism.
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling
TLDR
The results indicate that CYGB is expressed in vessels primarily in differentiated medial VSM cells where it regulates neointima formation and inhibits apoptosis after injury.
Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner
TLDR
Results of the present study provide a possible connection between a uremic toxin and the desensitization of the oxygen-sensing mechanism in EPO-producing cells, which may partly explain inadequate EPO production in hypoxic kidneys of CKD patients.
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References

SHOWING 1-10 OF 43 REFERENCES
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TLDR
Results indicate that Cygb/STAP is a tissue globin uniquely localized in splanchnic fibroblastic cell lineage and may play a role in fibrotic organ disorder.
Cytoglobin Is a Stress-responsive Hemoprotein Expressed in the Developing and Adult Brain
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TLDR
The hypothesis that Cygb is an oxygen-responsive tissue hemoglobin expressed in distinct regions of the normoxic and hypoxic brain and may play a key role in the response of the brain to a hypoxic insult is supported.
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TLDR
The negative correlation, after reoxygenation, between neuroglobin protein level and H2O2 concentration is a first proof of a reactive oxygen species‐scavenging function for neuroglobar, and apoptotic cell death after hypoxia is for the first time demonstrated in heart and liver.
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TLDR
The negative correlation, after reoxygenation, between neuroglobin protein level and H( 2)O(2) concentration is a first proof of a reactive oxygen species-scavenging function for neuroglobar, and apoptotic cell death after hypoxia is for the first time demonstrated in heart and liver.
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TLDR
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TLDR
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TLDR
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Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
TLDR
The first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene is shown, using biopsies and sputum samples from patients with and without lung cancer.
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