Cytogenetics of chronic myeloproliferative disorders and related myelodysplastic syndromes.

@article{Adeyinka2003CytogeneticsOC,
  title={Cytogenetics of chronic myeloproliferative disorders and related myelodysplastic syndromes.},
  author={Adewale Adeyinka and Gordon W. Dewald},
  journal={Hematology/oncology clinics of North America},
  year={2003},
  volume={17 5},
  pages={1129-49}
}
The only MPD associated with any specific chromosome anomaly is CML, which is linked with t(9;22)(q34;q11.2) or a variant of this anomaly. An association exists for del(13)(q12q14) and CIMF; t(5;12)(q33;p13) and CEL; and del(20q11), +8, and +9 and PV, but these anomalies can be seen in various hematologic malignancies. The most common chromosomal anomalies among MPD in order of frequency are t(9;22)(q34;q11.2), -Y, +8, +9, -7, del(20) (q11q13), del(13)(q12q14), del(5)(q13q33), and del(12)(p12… CONTINUE READING