Cytogenetics of childhood T-cell leukemia.

  title={Cytogenetics of childhood T-cell leukemia.},
  author={Susana C. Raimondi and Frederick G. Behm and Paula K Roberson and Ching-Hon Pui and Gaston K. Rivera and Sharon B. Murphy and Dorothy L. Williams},
  volume={72 5},
The karyotypes of 57 cases of childhood T-cell acute lymphoblastic leukemia (ALL) were analyzed to establish the cytogenetic profile in this disease. Three questions were of particular interest. Do the chromosomal changes in T-cell ALL preferentially affect bands where genes encoding the T-cell receptor for antigen (TCR) have been mapped? Do alterations involving the TCR gene regions appear with any notable frequency in B-progenitor ALL? Do chromosomal abnormalities in this disease relate to… CONTINUE READING
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