Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint.

@article{Tomlinson1991CytogeneticsOA,
  title={Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint.},
  author={Gail E. Tomlinson and Perry D. Nisen and Charles Franklin Timmons and Nancy R. Schneider},
  journal={Cancer genetics and cytogenetics},
  year={1991},
  volume={57 1},
  pages={11-7}
}
A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis. 

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