Cytogenetics and molecular genetics in multiple myeloma.

  title={Cytogenetics and molecular genetics in multiple myeloma.},
  author={Rena Feinman and Jeffrey Sawyer and Johanna Hardin and Guido Tricot},
  journal={Hematology/oncology clinics of North America},
  volume={11 1},
Specific cytogenetic abnormalities have been identified in multiple myeloma that confer a poor prognosis, even with intensive chemotherapy and autotransplants. The identification and characterization of potential genes involved in these different chromosomal changes and their interplay with oncogenes and tumor suppressor genes controlling cellular growth and apoptosis is the major focus of this review.