Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone.

@article{Dimopoulos2015CytogeneticsAL,
  title={Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone.},
  author={Meletios Athanasios Dimopoulos and Katja C. Weisel and Kevin W. Song and Michel Delforge and Lionel Karlin and Hartmut Goldschmidt and Philippe Moreau and Anne Banos and Albert Oriol and Laurent Garderet and Michele Cavo and Valentina Ivanova and Adr{\'i}an Alegre and Joaquin Martinez-Lopez and Christine I. Chen and Andrew Spencer and Stefan Knop and Nizar Jacques Bahlis and Christoph Renner and Xin Yu and Kevin Hong and Lars Axel Sternas and Christian J. D. Jacques and Mohamed H. Zaki and Jes{\'u}s Fernando San Miguel},
  journal={Haematologica},
  year={2015},
  volume={100 10},
  pages={1327-33}
}
Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had… CONTINUE READING
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Pomalidomide plus low - dose dexamethasone in relapsed or refractory multiple myeloma ( RRMM ) with deletion ( del ) 17 p and / or translocation t ( 4 ; 14 )

X Leleu, L Karlin, M Macro
Blood • 2013

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