Cytogenetically uninformative or Ph{sup 1} negative patients with CML should be evaluated by FISH with bcr/abl probes

@inproceedings{Brothman1994CytogeneticallyUO,
  title={Cytogenetically uninformative or Ph\{sup 1\} negative patients with CML should be evaluated by FISH with bcr/abl probes},
  author={Lisa J. Brothman and Alberto Grover and M Issa},
  year={1994}
}
Identification of the Ph{sup 1} translocation in chronic myelogenous leukemia (CML) is both diagnostically and prognostically important. Our laboratory has established a policy for the use of fluorescence in situ hybridization (FISH) with the Mbcr/abl probe (Oncor) to ensure that the most complete information available is obtained. Bone marrow or unstimulated peripheral blood is cultured, harvested and analyzed according to routine laboratory protocol. If the patient is Ph{sup 1} positive, the… CONTINUE READING