Cytogenetical characterisation of Chinese hamster 43-3B transferants with the amplified or non-amplified human DNA repair gene ERCC-1.

@article{Darroudi1989CytogeneticalCO,
  title={Cytogenetical characterisation of Chinese hamster 43-3B transferants with the amplified or non-amplified human DNA repair gene ERCC-1.},
  author={Firouz Darroudi and Andries Westerveld and Adayapalam Tyagarajan Natarajan},
  journal={Mutation research},
  year={1989},
  volume={212 2},
  pages={113-22}
}
A comparative study on the biological responses to different mutagens (UV, 4NQO, MMC, MMS and EMS) was made on CHO wild-type cells (CHO-9), its UV-hypersensitive mutant 43-3B, and 2 types of its transferants, i.e., one containing a few copies of the human repair gene ERCC-1 and the other having more than 100 copies of ERCC-1 (due to gene amplification… CONTINUE READING