Cytogenetic landscape of paired neurospheres and traditional monolayer cultures in pediatric malignant brain tumors.

Abstract

BACKGROUND New therapeutic targets are needed to eliminate cancer stem cells (CSCs). We hypothesize that direct comparison of paired CSCs and nonstem tumor cells (NSTCs) will facilitate identification of primary "driver" chromosomal aberrations that can serve as diagnostic markers and/or therapeutic targets. METHODS We applied spectral karyotyping and G… (More)
DOI: 10.1093/neuonc/nou337

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