Cytogenetic instability in a family with gastric cancer recurrence.

  title={Cytogenetic instability in a family with gastric cancer recurrence.},
  author={R Di Lernia and Ivana Magnani and Luisa Doneda and Romana Rizzi and L Larizza},
  journal={Cancer genetics and cytogenetics},
  volume={27 2},
An index case with a congenital malformation syndrome enabled detection of a family that had a previous history of spontaneous abortuses and recurrence of neoplasia through three generations. Cytogenetic analysis performed on lymphocytes from 11 subjects in the second and third generation showed karyotypic alterations in both tumor bearers and apparently normal subjects. Chromosome variations consisted of: spontaneous chromosome fragility; chromosome translocations; polymorphisms in the… CONTINUE READING