Cytogenetic evaluation of the mechanism of cell death induced by the novel anthracenyl-amino acid topoisomerase II catalytic inhibitor NU/ICRF 500.

@article{Cummings1995CytogeneticEO,
  title={Cytogenetic evaluation of the mechanism of cell death induced by the novel anthracenyl-amino acid topoisomerase II catalytic inhibitor NU/ICRF 500.},
  author={Jeffrey Cummings and Adrian T. Sumner and Anne M Slavotinek and Ian Meikle and Janet S. Macpherson and John F. Smyth},
  journal={Mutation research},
  year={1995},
  volume={344 1-2},
  pages={55-62}
}
Anthracenyl-amino acid/dipeptides are novel topoisomerase (topo) inhibitors which can be actively cytotoxic in the low microM range. The present studies have been performed to determine whether cells treated with the topo II catalytic inhibitor NU/ICRF 500 (serine derivative) would manifest cytogenetic lesions consistent with its proposed mechanism of enzyme inhibition. Three other compounds were included for comparison: NU/ICRF 505 (tyrosine) which stabilises topo I cleavable complexes, NU… CONTINUE READING