Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.

@article{Patnaik2016CytogeneticAM,
  title={Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.},
  author={Mrinal S Patnaik and Ayalew Tefferi},
  journal={Blood cancer journal},
  year={2016},
  volume={6},
  pages={e393}
}
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnormalities include; trisomy 8, -Y, -7/del(7q), trisomy 21 and del(20q), with the Mayo-French risk… CONTINUE READING
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