Cytogenetic and Molecular Characterization of Tumors in Nude Mice Derived from a Multidrug-resistant Human Leukemia Cell Line 1

@inproceedings{Hill2006CytogeneticAM,
  title={Cytogenetic and Molecular Characterization of Tumors in Nude Mice Derived from a Multidrug-resistant Human Leukemia Cell Line 1},
  author={Anna B. Hill and William Beck and Jeffrey M. Trent},
  year={2006}
}
We have evaluated whether selection of a human tumor leukemic line for resistance to vinblastine (Velban; VLB) alters its tumorigenicity. To address this question, CEM and CEM/VLBIOo cells (which express the multiple drug-resistant (MDR) phenotype via amplification of the Pglycoprotein gene] were characterized by several techniques including chromosome banding, in situ hybridization. Southern blotting, RNA dot blotting, in vitro drug sensitivity, and tumorigenicity in nude mice. Analysis of the… CONTINUE READING