Cytogenetic aberrations detected by flow cytometry and fluorescence in situ hybridization in colorectal cancers: two cytogenetic pathways in colorectal carcinogenesis.


We measured DNA content by flow cytometry and determined the number of chromosomes 7, 17 and 18 by fluorescence in situ hybridization using DNA probes in 38 sporadic colorectal adenocarcinomas including 14 early cancers. Based on DNA ploidy and the copy number of chromosome 18, colorectal cancers were divided into two groups. In early cancers (mucosal and… (More)


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