Cytogenetic Studies in Patients with Acute Myeloid Leukemia Following a Myelodysplastic Syndrome.

@article{Weh1991CytogeneticSI,
  title={Cytogenetic Studies in Patients with Acute Myeloid Leukemia Following a Myelodysplastic Syndrome.},
  author={H. J. Weh and Rolf Kuse and Doris Seeger and Stefan Suciu and Dieter Kurt Hossfeld},
  journal={Leukemia & lymphoma},
  year={1991},
  volume={3 5-6},
  pages={423-7}
}
Between 1981 and 1988, thirty-nine patients with acute myeloid leukemia (AML) following a de novo myelodysplastic syndrome (n-MDS) were studied cytogenetically. The chromosomal aberration rate was 59%. The anomalies most often found were: complex (four or more) aberrations (n = 6), a 5q- chromosome (n = 6), monosomy 7 or a 7q- chromosome and trisomy 8 as the sole defect (n = 3). Incidence and types of chromosomal aberrations were approximately the same as in myelodysplastic syndromes and in 191… CONTINUE READING