Cytogenetic-Morphologic Correlations in Aneurysmal Bone Cyst, Giant Cell Tumor of Bone and Combined Lesions. A Report from the CHAMP Study Group

@article{Sciot2000CytogeneticMorphologicCI,
  title={Cytogenetic-Morphologic Correlations in Aneurysmal Bone Cyst, Giant Cell Tumor of Bone and Combined Lesions. A Report from the CHAMP Study Group},
  author={Rafa{\"e}l Sciot and Howard Dorfman and Peter P. M. Brys and Paola dal Cin and Ivo de Wever and Christopher D. M. Fletcher and Kjell Jonson and Nils Mandahl and Fredrik Mertens and Felix Mitelman and Juan Rosai and Anders Rydholm and I. Samson and G. Tallini and H. Van den Berghe and Roberta Vanni and Helena Will{\'e}n},
  journal={Modern Pathology},
  year={2000},
  volume={13},
  pages={1206-1210}
}
Aneurysmal bone cyst and giant cell tumor of bone are relatively rare bone tumors that sometimes coexist. We examined the karyotypes of 3 aneurysmal bone cysts, 12 giant cell tumors, and 3 combined lesions. All aneurysmal bone cysts showed involvement of chromosome segments 17p11–13 and/or 16q22. In addition, in 1 of the 3 giant cell tumors with secondary aneurysmal bone cyst, both chromosome bands were rearranged as well, albeitnot in a balanced translocation. Seven out of 12 giant cell tumors… CONTINUE READING
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