Cytogenetic Effects Induced by Cytochalasin B in Chinese Hamster Ovary Cells.

Abstract

We determined the kinetics of the induction of chromosomal aberrations and micronuclei (MN) by mitomycin C (MMC, 0.1 &mgr;g/ml) in Chinese hamster ovary (CHO) cells treated with cytochalasin B (Cyt-B, 3 &mgr;g/ml). In cells treated with Cyt-B as well as with Cyt-B plus MMC the highest yield of binucleated cells was obtained 24 h after treatment. After 40 h… (More)

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