Cytogenetic 2; 18 and 18; 22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes.

@article{Tashiro1992Cytogenetic21,
  title={Cytogenetic 2; 18 and 18; 22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes.},
  author={Satoshi Tashiro and Masahiko Takechi and Hiroya Asou and Katsuhiko Takauchi and Taiichi Kyo and Hiroo Dohy and Mika Kikuchi and Nanao Kamada and Yoshihide Tsujimoto},
  journal={Oncogene},
  year={1992},
  volume={7 3},
  pages={573-7}
}
The majority of follicular lymphoma cells carry the typical chromosome translocation 14;18, which juxtaposes the bcl-2 gene to the immunoglobulin heavy-chain (IgH) gene. Variant translocations of the bcl-2 gene to the Ig lambda or Ig kappa gene have been found by molecular biological techniques in a significant fraction (approximately 10%) of chronic lymphocytic leukemia (CLL). However, there have been no reports describing the presence of cytogenetic 18;22 and 2;18 translocations in CLL, in… CONTINUE READING

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