Cytogenetic "rogue" cells: what is their frequency, origin, and evolutionary significance?

  title={Cytogenetic "rogue" cells: what is their frequency, origin, and evolutionary significance?},
  author={Akio A. Awa and James V. Neel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 4},
Among 102,170 cultured lymphocytes obtained from 9818 individuals from Hiroshima, Japan, aged 9 to 37 years and scored for chromosomal abnormalities, 24 cells that exhibited an extreme degree of damage were encountered. The damage consists of multiple dicentric and even tricentric chromosomes, as well as numerous fragments, many with the appearance of "double minutes." The occurrence of these cells was not correlated with parental exposure to the atomic bomb, age, sex, year, or season. They… CONTINUE READING

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