Cytofluorescence localization of anthracycline antibiotics.

  title={Cytofluorescence localization of anthracycline antibiotics.},
  author={Merrill J. Egorin and Ronald E. Clawson and Jordan L. Cohen and Linda A Ross and Nicholas R. Bachur},
  journal={Cancer research},
  volume={40 12},
Previous fluorescence microscopic studies have shown daunorubicin (DNR) and Adriamycin (ADR) are localized in cell nuclei, whereas trifluoroacetyladriamycin-14-valerate is local ized in the cytoplasm. Using cultured cells, we correlated structural characteristics of a series of anthracycline antibiotics with cellular disposition and metabolic response. When ob served under fluorescence microscopy, DNR, ADR, A/,W-dimethyldaunorubicin, A/,/V-dimethyladriamycin, and 4'-epiadriamycin localized in… CONTINUE READING


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Publications referenced by this paper.
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Differential fluorescent staining of human 4675 on April 16, 2017

C. C. Lin, J. H. Van De Sande
J. Egorin et al. chromosomes with daunomycin and Adriamycin. Science • 1980
View 1 Excerpt

Estimation of viable cell number by fluorescence: application to lymphotoxin assay

R. N. Odders, N. R. Bachur
J. Immunol. Methods, • 1980
View 1 Excerpt

Clinical study of aclacinomycin A.

Cancer treatment reports • 1979
View 1 Excerpt

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