Cytocidal Drugs Nontoxic Prodrug : A Strategy for Tumor-selective Activation of Proton-mediated Liberation of Aldophosphamide from a Updated Version

Based on the findings that the pH in malignant tumors can be prefer entially decreased by stimulation of their aerobic glycolysis, acid-sensible prodrugs, which are nearly nontoxic at physiological pH, were synthe sized. At lower pH, however, these compounds are cleaved with liberation of a cytotoxic species. The prototypic drug compound 2-hexenopyranoside… CONTINUE READING