Cytocidal Activity of a Synthetic Isoprenoid, N‐Solanesyl‐N, N′‐bis(3,4‐dimethoxy‐benzyl)ethylenediamine, and Its Potentiation of Antitumor Drugs against Multidrug‐resistant and Sensitive Cells in vitro

@inproceedings{Suzuki1990CytocidalAO,
  title={Cytocidal Activity of a Synthetic Isoprenoid, N‐Solanesyl‐N, N′‐bis(3,4‐dimethoxy‐benzyl)ethylenediamine, and Its Potentiation of Antitumor Drugs against Multidrug‐resistant and Sensitive Cells in vitro},
  author={Hideo Suzuki and Akihiro Tomida and Toshio Nishimura},
  booktitle={Japanese journal of cancer research : Gann},
  year={1990}
}
A synthetic isoprenoid, N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine (SDB-ethylenediamine), inhibited the colony formation of multidrug-resistant mutant cell lines derived from Chinese hamster V79 (V79/ADM) and human hepatoma PLC/PRF/5 (PLC/COL) cells to a greater extent than that of the parental cells. When combined with other clinically useful antitumor agents, it potentiated the cytotoxic activity of almost all kinds of drugs tested including adriamycin (ADM), actinomycin D… CONTINUE READING