Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda.

@article{Stegeman1997CytochromesP,
  title={Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda.},
  author={John J. Stegeman and Bruce R. Woodin and Harpal Singh and Marjorie F. Oleksiak and Malin Celander},
  journal={Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology},
  year={1997},
  volume={116 1},
  pages={61-75}
}
Hepatic microsomes prepared from 10 fish species from Bermuda were studied to establish features of cytochrome P450 (CYP) systems in tropical marine fish. The majority (7/10) of the species had total P450 content between 0.1 and 0.5 nmol/mg, and cytochrome b5 content between 0.025 and 0.25 nmol/mg. Ethoxycoumarin O-deethylase (ECOD) and aminopyrine N-demethylase (APND) rates in these 7 species were 0.23-2.1 nmol/min/mg and 0.5-11 nmol/min/mg, respectively, similar to rates in many temperate… CONTINUE READING

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