Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.

  title={Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.},
  author={Gunilla Sandborgh Englund and Patrik Lundquist and Cristine Skogastierna and Jenny Johansson and Janet Hoogstraate and Lovisa Afzelius and Tommy B. Andersson and Denis Projean},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={42 3},
Drug transporter inhibitors are important tools to elucidate the contribution of transporters to drug disposition both in vitro and in vivo. These inhibitors are often unselective and affect several transporters as well as drug metabolizing enzymes, which can make experimental results difficult to interpret with confidence. We therefore tested 14 commonly used P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug-resistance associated protein (MRP) inhibitors as… CONTINUE READING


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compounds with four fluorometric substrates

  • A Treiber, R Schneiter, S Häusler, B Stieger
  • Drug Metab Dispos
  • 2007
Highly Influential
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