Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis.

  title={Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis.},
  author={Jian-kang Chen and J. Capdevila and Raymond C Harris},
  journal={Molecular and cellular biology},
  volume={21 18},
The ubiquitous cytochrome P450 hemoproteins play important functional roles in the metabolism and detoxification of foreign chemicals. However, other than established roles in cholesterol catabolism and steroid hormone biosynthesis, their cellular and/or organ physiological functions remain to be fully characterized. Here we show that the cytochrome P450 epoxygenase arachidonic acid metabolite 14,15-epoxyeicosatrienoic acid (14,15-EET) inhibits apoptosis induced by serum withdrawal, H(2)O(2… CONTINUE READING


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