Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).

@article{Lamb2003CytochromePC,
  title={Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).},
  author={David Christopher Lamb and Haruo Ikeda and David R. Nelson and Jun Ishikawa and Tove Skaug and Colin J Jackson and Satoshi Ōmura and Michael R. Waterman and Steven L Kelly},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={307 3},
  pages={610-9}
}
The genus Streptomyces produces about two-thirds of naturally occurring antibiotics and a wide array of other secondary metabolites, including antihelminthic agents, antitumor agents, antifungal agents, and herbicides. The newly completed genome sequence of the avermectin-producing bacterium Streptomyces avermitilis contains 33 cytochromes p450 (CYPs), many more than the 18 observed in Streptomyces coelicolor A3(2). Some of the likely metabolic functions are reported together with their genomic… CONTINUE READING
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