Cytochrome p450 and chemical toxicology.

@article{Guengerich2008CytochromePA,
  title={Cytochrome p450 and chemical toxicology.},
  author={F. Guengerich},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 1},
  pages={
          70-83
        }
}
  • F. Guengerich
  • Published 2008
  • Chemistry, Medicine
  • Chemical research in toxicology
The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the roles of P450s in chemical toxicology have appeared in Chemical Research in Toxicology. Today, our basic understanding of many of the human P450s is relatively well-established, in terms of the details of the individual genes, sequences, and basic catalytic mechanisms. Crystal structures of several of the major human P450s are now in hand. The animal P450s are still… Expand
Inhibition and induction of human cytochrome P450 enzymes: current status
Yeast as a humanized model organism for biotransformation-related toxicity.
Computational prediction of cytochrome P450 inhibition and induction.
  • H. Kato
  • Chemistry, Medicine
  • Drug metabolism and pharmacokinetics
  • 2019
Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism
Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 231 REFERENCES
Characterization of human cytochrome P450 enzymes
  • F. Guengerich
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1992
Human cytochrome P-450 enzymes.
Multiple Sequential Steps Involved in the Binding of Inhibitors to Cytochrome P450 3A4*
Structural basis for ligand promiscuity in cytochrome P450 3A4
CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies
  • Q. Ma, A. Y. Lu
  • Biology, Medicine
  • Drug Metabolism and Disposition
  • 2007
Function of human cytochrome P450s: characterization of the orphans.
...
1
2
3
4
5
...