Cytochrome p450 and chemical toxicology.

  title={Cytochrome p450 and chemical toxicology.},
  author={F. Peter Guengerich},
  journal={Chemical research in toxicology},
  volume={21 1},
  • F. Guengerich
  • Published 2008
  • Biology, Chemistry
  • Chemical research in toxicology
The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the roles of P450s in chemical toxicology have appeared in Chemical Research in Toxicology. Today, our basic understanding of many of the human P450s is relatively well-established, in terms of the details of the individual genes, sequences, and basic catalytic mechanisms. Crystal structures of several of the major human P450s are now in hand. The animal P450s are still… 

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