Cytochrome p450 and chemical toxicology.

@article{Guengerich2008CytochromePA,
  title={Cytochrome p450 and chemical toxicology.},
  author={F. Guengerich},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 1},
  pages={
          70-83
        }
}
  • F. Guengerich
  • Published 2008
  • Chemistry, Medicine
  • Chemical research in toxicology
The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the roles of P450s in chemical toxicology have appeared in Chemical Research in Toxicology. Today, our basic understanding of many of the human P450s is relatively well-established, in terms of the details of the individual genes, sequences, and basic catalytic mechanisms. Crystal structures of several of the major human P450s are now in hand. The animal P450s are still… Expand
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In this most complex humanized mouse model reported to date, the cytochromes P450 function as predicted and it is illustrated how these mice can be applied to predict drug-drug interactions in humans. Expand
Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme
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