Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium.

@article{Dorman2002CytochromeOI,
  title={Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium.},
  author={David Dorman and Frederic J-M Moulin and Brian E McManus and Kristen C Mahle and R. Arden James and Melanie F Struve},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={65 1},
  pages={18-25}
}
Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of cytochrome oxidase is the primary biochemical effect associated with lethal H2S exposure. The objective of this study was to evaluate the relationship between the concentration of sulfide and cytochrome oxidase activity in target tissues following acute exposure to sublethal concentrations of inhaled H2S. Hindbrain, lung, liver, and nasal (olfactory and respiratory epithelial) cytochrome oxidase activity and… CONTINUE READING
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