Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.

@article{Gogvadze2001CytochromeCR,
  title={Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.},
  author={Vladimir Gogvadze and John D. Robertson and Boris Zhivotovsky and Sten Orrenius},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={19066-71}
}
Release of cytochrome c from mitochondria is a key initiative step in the apoptotic process, although the mechanisms regulating this event remain elusive. In the present study, using isolated liver mitochondria, we demonstrate that cytochrome c release occurs via distinct mechanisms that are either Ca(2+)-dependent or Ca(2+)-independent. An increase in mitochondrial matrix Ca(2+) promotes the opening of the permeability transition (PT) pore and the release of cytochrome c, an effect that is… CONTINUE READING
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