Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

@inproceedings{Schll2015CytochromeCO,
  title={Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6},
  author={S Sch{\"u}ll and Stefan G{\"u}nther and Susanne Brodesser and J M Seeger and Bettina Tosetti and Kirsten Wiegmann and C Pongratz and Fernando D{\'i}az and Andreas Witt and Marcel Andr{\'e}e and Kerstin Brinkmann and Martin Kr{\"o}nke and Rudolf Josef Wiesner and Hamid Kashkar},
  booktitle={Cell Death and Disease},
  year={2015}
}
Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, we show that the specific alteration of the cytochrome c oxidase (COX), representing a common defect found in mitochondrial diseases, facilitates mitochondrial apoptosis in response to oxidative… CONTINUE READING