Cytochrome c in the apoptotic and antioxidant cascades

@article{Skulachev1998CytochromeCI,
  title={Cytochrome c in the apoptotic and antioxidant cascades},
  author={Vladimir P. Skulachev},
  journal={FEBS Letters},
  year={1998},
  volume={423}
}

Redox regulation of apoptosis before and after cytochrome C release

This review summarizes what is known about the biological role of ROS and its targets in apoptosis with an emphasis on its intricate connections to mitochondria and the basic components of cell death.

Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death.

The teniposide-induced increase of cytochrome c was inhibited by cycloheximide, indicating new protein synthesis, and the increase in mitochondrial protein expression may play a role in the early cellular defense against anticancer drugs.

Molecular mechanisms of apoptosis. Structure of cytochrome c-cardiolipin complex

It is shown that under the action of cooperative forces, the protein in the globule expands greatly in volume, its conformation is modified, and the protein becomes a peroxidase in extended membranes, such as giant monolayer liposomes, and very likely in biological membranes, the formation of nanospheres of cytochrome c-cardiolipin complex causes fusion of membrane sections and dramatic chaotization of the whole membrane structure.
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