Cytochrome c folding pathway: kinetic native-state hydrogen exchange.

@article{Hoang2002CytochromeCF,
  title={Cytochrome c folding pathway: kinetic native-state hydrogen exchange.},
  author={Linh Hoang and Sabrina B{\'e}dard and Mallela M G Krishna and Yan Lin and S. Walter Englander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 19},
  pages={12173-8}
}
Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each. Results obtained define a cytochrome c intermediate seen only poorly before and place it early on the major unfolding pathway. Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before. 

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