Cytochrome c and c1 heme lyases are essential in Plasmodium berghei.

Abstract

Malaria parasites possess a de novo heme synthetic pathway. Interestingly, this pathway is dispensable during the blood stages of development in mammalian hosts. The assembly of the two most important hemeproteins, cytochromes c and c1, is mediated by cytochrome heme lyase enzymes. Plasmodium spp. possess two cytochrome heme lyases encoded by separate genes… (More)
DOI: 10.1016/j.molbiopara.2016.08.003

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