Cytochrome b5 Is Essential for Cytochrome P450 6D1-Mediated Cypermethrin Resistance in LPR House Flies

@article{Zhang1996CytochromeBI,
  title={Cytochrome b5 Is Essential for Cytochrome P450 6D1-Mediated Cypermethrin Resistance in LPR House Flies},
  author={Zhang and H Scott},
  journal={Pesticide biochemistry and physiology},
  year={1996},
  volume={55 2},
  pages={150-6}
}
  • Zhang, H Scott
  • Published 1996 in Pesticide biochemistry and physiology
Cytochrome P450 monooxygenase-mediated detoxification is a very important mechanism of resistance to insecticides. In the LPR strain of house fly, the major mechanism of resistance to pyrethroids is monooxygenase-mediated metabolism due to the overexpression of cytochrome P450 6D1 (CYP6D1). Although the role of CYP6D1 in pyrethroid resistance has been demonstrated, there is no information as to whether cytochrome b5 is involved in this reaction and what the major CYP6D1-specific metabolite is… CONTINUE READING

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