Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.

Abstract

Ellipticine is a pro-drug, whose activation is dependent on its oxidation by cytochromes P450 (CYP) and peroxidases. Cytochrome b(5) alters the ratio of ellipticine metabolites formed by isolated reconstituted CYP1A1 and 1A2, favoring formation of 12-hydroxy- and 13-hydroxyellipticine metabolites implicated in ellipticine-DNA adduct formation, at the… (More)
DOI: 10.1016/j.bcp.2011.06.003

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@article{Kotrbov2011CytochromeBS, title={Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.}, author={Věra Kotrbov{\'a} and Barbora Mr{\'a}zov{\'a} and Michaela Moserov{\'a} and V{\'a}clav Mart{\'i}nek and Petr Hodek and Jiř{\'i} Hude{\vc}ek and Eva Frei and Marie Stiborov{\'a}}, journal={Biochemical pharmacology}, year={2011}, volume={82 6}, pages={669-80} }