Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes.

@article{Segal1992CytochromeBI,
  title={Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes.},
  author={A. Segal and I. West and F. Wientjes and J. Nugent and A. Chavan and B. Haley and R. Garc{\'i}a and H. Rosen and G. Scrace},
  journal={The Biochemical journal},
  year={1992},
  volume={284 ( Pt 3)},
  pages={
          781-8
        }
}
The NADPH oxidase of phagocytic cells is important for the efficient killing and digestion of ingested microbes. A very unusual low-potential cytochrome b (b-245) is the only redox molecule to have been identified in this system. The FAD-containing flavoprotein that binds NADPH and transfers electrons to the cytochrome has eluded identification for three decades. We show here that the haem/FAD ratio in the membranes does not change significantly on activation of this oxidase, indicating that… Expand
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