Cytochrome P450cam: crystallography, oxygen activation, and electron transfer.

@article{Poulos1992CytochromePC,
  title={Cytochrome P450cam: crystallography, oxygen activation, and electron transfer.},
  author={Thomas L Poulos and Reetta Raag},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1992},
  volume={6 2},
  pages={
          674-9
        }
}
Several crystal structures of various substrate and inhibited complexes of the camphor monoxygenase, cytochrome P450cam from Pseudomonas putida, are now available. These structures, together with mutagenesis, biochemical, and biophysical studies, have allowed for a detailed penetration into the problem of how P450s activate molecular oxygen, control stereoselectivity, and transfer electrons. This review will provide a summary of the crystallographic work in light of what these structures have… CONTINUE READING

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