Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

@article{Froemel2012CytochromePA,
  title={Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques},
  author={Timo Froemel and K. Kohlstedt and R. Popp and X. Yin and Khader Awwad and Eduardo Barbosa-Sicard and A. C. Thomas and Ralf Lieberz and M. Mayr and I. Fleming},
  journal={Basic Research in Cardiology},
  year={2012},
  volume={108},
  pages={1-12}
}
  • Timo Froemel, K. Kohlstedt, +7 authors I. Fleming
  • Published 2012
  • Biology, Medicine
  • Basic Research in Cardiology
  • Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators. The latter play an important role in vascular homeostasis, angiogenesis, and inflammation. As little is known about the functional importance of extra-vascular sources of lipid epoxides, we focused on determining whether lipid epoxide-generating CYP isoforms are expressed in human monocytes/macrophages. Epoxides were generated by freshly… CONTINUE READING
    37 Citations
    The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling.
    • I. Fleming
    • Biology, Medicine
    • Vascular pharmacology
    • 2016
    • 31
    Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer
    • 1
    • PDF
    PHARMREV007781 1106..1140
    • 2014
    The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease
    • I. Fleming
    • Biology, Medicine
    • Pharmacological Reviews
    • 2014
    • 86
    Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
    • 21
    • Highly Influenced
    • PDF
    Angiogenesis and vascular stability in eicosanoids and cancer
    • 9

    References

    SHOWING 1-10 OF 51 REFERENCES
    Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity
    • 62
    • Highly Influential
    • PDF
    Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes.
    • 32
    • Highly Influential
    Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
    • Y. Deng, M. Edin, +12 authors C. Lee
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2011
    • 121
    Cytochrome P450-dependent eicosanoid production and crosstalk
    • I. Fleming
    • Medicine, Biology
    • Current opinion in lipidology
    • 2011
    • 23
    Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
    • 17
    • Highly Influential
    • PDF
    The cytochrome P450 pathway in angiogenesis and endothelial cell biology
    • I. Fleming
    • Biology, Medicine
    • Cancer and Metastasis Reviews
    • 2011
    • 34
    Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
    • 1,024
    • PDF
    Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotype
    • 42