Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

  title={Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques},
  author={Timo Froemel and K. Kohlstedt and R. Popp and X. Yin and Khader Awwad and Eduardo Barbosa-Sicard and A. C. Thomas and Ralf Lieberz and M. Mayr and I. Fleming},
  journal={Basic Research in Cardiology},
  • Timo Froemel, K. Kohlstedt, +7 authors I. Fleming
  • Published 2012
  • Biology, Medicine
  • Basic Research in Cardiology
  • Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators. The latter play an important role in vascular homeostasis, angiogenesis, and inflammation. As little is known about the functional importance of extra-vascular sources of lipid epoxides, we focused on determining whether lipid epoxide-generating CYP isoforms are expressed in human monocytes/macrophages. Epoxides were generated by freshly… CONTINUE READING
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