Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.

@article{Shen1997CytochromePI,
  title={Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.},
  author={Shing Chuan Shen and Stefan Hargus and Brian M. Martin and Lance R. Pohl},
  journal={Chemical research in toxicology},
  year={1997},
  volume={10 4},
  pages={420-3}
}
Diclofenac antiserum was previously developed and used to detect protein adducts of metabolites of dichlofenac in livers of mice and rats. In this study, the antibody has been used to facilitate the purification of a major 51 kDa microsomal adduct of diclofenac from the liver microsomes of male rats that were treated with diclofenac. The adduct was identified as male-specific cytochrome P4502C11 based on its N-terminal amino acid sequence, reaction with a cytochrome P4502C11 antibody, and by… CONTINUE READING

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