Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan.

@article{Murata1998CytochromePA,
  title={Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan.},
  author={Mitsushige Murata and Taizo Shiraishi and Kazuo Fukutome and Masatoshi Watanabe and Minako Nagao and Yoshitsugu Kubota and Hidemi Ito and Juichi Kawamura and Ryuichi Yatani},
  journal={Japanese journal of clinical oncology},
  year={1998},
  volume={28 11},
  pages={657-60}
}
BACKGROUND The p53 mutation spectrum of prostate cancers developing in Japan indicates a role for environmental factors. This suggests there might be differences in susceptibility due to genetic polymorphisms in metabolic activation enzyme genes. We analyzed genetic polymorphisms of the xenobiotic-metabolizing enzymes, CYP1A1 and GSTM1. METHOD Genotyping of CYP1A1 and GSTM1 was investigated by using allele-specific PCR in 115 prostate cancer (PCa) patients and 204 control patients. RESULTS… CONTINUE READING

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